AGRP Information: AGRP Protein, AGRP Antibody and AGRP Gene

AGRP Gene family

AGRP Protein

AGRP protein function

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250, ECO:0000269|PubMed:10371151, ECO:0000269|PubMed:11145747, ECO:0000269|PubMed:15927146, ECO:0000269|PubMed:17041250, ECO:0000269|PubMed:9892020}.

AGRP protein expression

Tissue specificity

Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

AGRP protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)


AGRP gene / cDNA is a protein-coding gene which located on 16q22.1. The AGRP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.187 organisms have orthologs with human gene AGRP.