AHCYL1/IRBIT Information: AHCYL1/IRBIT Protein, AHCYL1/IRBIT Antibody and AHCYL1/IRBIT Gene

AHCYL1/IRBIT Gene family


AHCYL1/IRBIT protein function

Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).

AHCYL1/IRBIT protein expression

Tissue specificity

Expressed in dendritic cells.


Expression increases markedly during activation of blood and skin DC (Langerhans cells), but is diminished in terminally differentiated tonsil DC.

AHCYL1/IRBIT protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)


There are 1 AHCYL1/IRBIT antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ICC/IF, IP. There are 1 AHCYL1/IRBIT antibody for WB, 1 AHCYL1/IRBIT antibody for IHC-P, 1 AHCYL1/IRBIT antibody for ICC/IF, 1 AHCYL1/IRBIT antibody for IP. Among all these AHCYL1/IRBIT antibodies, there are 1 anti-AHCYL1/IRBIT rabbit polyclonal antibodies . All the AHCYL1/IRBIT anbodies are produced in house and all are in stock. AHCYL1/IRBIT antibody customerized service is available.


AHCYL1 cDNA / gene is a gene with protein product which located on 1p13.3. The AHCYL1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and mosquito. 228 organisms have orthologs with human gene AHCYL1.