Aryl Hydrocarbon Receptor Information: Aryl Hydrocarbon Receptor Protein, Aryl Hydrocarbon Receptor Antibody and Aryl Hydrocarbon Receptor Gene

Aryl Hydrocarbon Receptor Gene family

Aryl Hydrocarbon Receptor Protein

Aryl Hydrocarbon Receptor protein function

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:10395741, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:7961644}.

Aryl Hydrocarbon Receptor protein expression

Tissue specificity

Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.

Induction

Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).

Aryl Hydrocarbon Receptor protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    848.00
  • Mass (KDa)
    96.00

Aryl Hydrocarbon Receptor Antibody

There are 2 Aryl Hydrocarbon Receptor antibodies which are validated in multiple tissues with various applications, including IHC-P, ICC/IF. There are 2 Aryl Hydrocarbon Receptor antibody for IHC-P, 2 Aryl Hydrocarbon Receptor antibody for ICC/IF. Among all these Aryl Hydrocarbon Receptor antibodies, there are 2 anti-Aryl Hydrocarbon Receptor rabbit polyclonal antibodies . All the Aryl Hydrocarbon Receptor anbodies are produced in house and all are in stock. Aryl Hydrocarbon Receptor antibody customerized service is available.

Aryl Hydrocarbon Receptor Gene

AHR gene / cDNA is a protein-coding gene which located on 7p21.1. The AHR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.190 organisms have orthologs with human gene AHR.