AHRR Information: AHRR Protein, AHRR Antibody and AHRR Gene

AHRR Gene family

AHRR Protein

AHRR protein function

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.

AHRR protein expression

Tissue specificity

Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.

Induction

By 3-methylcholanthrene (3-MC) in MNCs from adults. By the heterodimer AHR/ARNT.

AHRR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    701.00
  • Mass (KDa)
    76.00

AHRR Gene

AHRR cDNA / gene is a gene with protein product which located on 5p15.33. The AHRR gene is conserved in chimpanzee, Rhesus monkey, mouse, rat, chicken, and frog. 208 organisms have orthologs with human gene AHRR.