AICDA Information: AICDA Protein, AICDA Antibody and AICDA Gene

AICDA Gene family

AICDA Protein

AICDA protein function

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).

AICDA protein expression

Tissue specificity

Strongly expressed in lymph nodes and tonsils.

Induction

Negatively regulated by microRNA-155 (miR-155).

AICDA protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    198.00
  • Mass (KDa)
    23.00

AICDA Gene

AICDA cDNA / gene is a gene with protein product which located on 12p13.31. The AICDA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 223 organisms have orthologs with human gene AICDA.