AIFM1/AIF Information: AIFM1/AIF Protein, AIFM1/AIF Antibody and AIFM1/AIF Gene

AIFM1/AIF Protein

AIFM1/AIF protein function

Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

AIFM1/AIF protein expression

Tissue specificity

Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers.

AIFM1/AIF protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    613.00
  • Mass (KDa)
    66.00

AIFM1/AIF Antibody

There are 5 AIFM1/AIF antibodies which are validated in multiple tissues with various applications, including IHC-P, WB, IP. There are 3 AIFM1/AIF antibody for IHC-P, 4 AIFM1/AIF antibody for WB, 3 AIFM1/AIF antibody for IP. Among all these AIFM1/AIF antibodies, there are 5 anti-AIFM1/AIF rabbit polyclonal antibodies . All the AIFM1/AIF anbodies are produced in house and all are in stock. AIFM1/AIF antibody customerized service is available.

AIFM1/AIF Gene

AIFM1 cDNA / gene is a gene with protein product which located on Xq26.1. The AIFM1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. 225 organisms have orthologs with human gene AIFM1.