AIFM2/AMID Information: AIFM2/AMID Protein, AIFM2/AMID Antibody and AIFM2/AMID Gene

AIFM2/AMID Protein

AIFM2/AMID protein function

Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.

AIFM2/AMID protein expression

Tissue specificity

Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.

Induction

Expression detected at 4 hours after induction by p53/TP53. Down-regulated in a wide range of human tumors.

AIFM2/AMID protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    373.00
  • Mass (KDa)
    40.00

AIFM2/AMID Gene

AIFM2 cDNA / gene is a gene with protein product which located on 10q22.1. The AIFM2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, M.oryzae, A.thaliana, rice, and frog. 235 organisms have orthologs with human gene AIFM2.