AIM2 Information: AIM2 Protein, AIM2 Antibody and AIM2 Gene

AIM2 Gene family

AIM2 Protein

AIM2 protein function

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:16432157, ECO:0000269|PubMed:17726700, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679, ECO:0000269|PubMed:20566831}.

AIM2 protein expression

Tissue specificity

Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.

Induction

By IFNG/IFN-gamma and IFNB1/IFN-beta.

AIM2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    343.00
  • Mass (KDa)
    38.00

AIM2 Antibody

There are 4 AIM2 antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P, ICC/IF, WB. There are 2 AIM2 antibody for ELISA, 1 AIM2 antibody for IHC-P, 1 AIM2 antibody for ICC/IF, 1 AIM2 antibody for WB. Among all these AIM2 antibodies, there are 4 anti-AIM2 rabbit polyclonal antibodies . All the AIM2 anbodies are produced in house and all are in stock. AIM2 antibody customerized service is available.

AIM2 Gene

AIM2 gene / cDNA is a protein-coding gene which located on 1q23.1-q23.2. The AIM2 gene is conserved in chimpanzee, Rhesus monkey, mouse, and rat.51 organisms have orthologs with human gene AIM2.