AK2 Information: AK2 Protein, AK2 Antibody and AK2 Gene

AK2 Gene family

AK2 Protein

AK2 protein function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}.

AK2 protein expression

Tissue specificity

Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).

AK2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    239.00
  • Mass (KDa)
    26.00

AK2 Antibody

There are 4 AK2 antibodies which are validated in multiple tissues with various applications, including ICC/IF, WB, ELISA, IHC-P, IP. There are 1 AK2 antibody for ICC/IF, 3 AK2 antibody for WB, 2 AK2 antibody for ELISA, 2 AK2 antibody for IHC-P, 1 AK2 antibody for IP. Among all these AK2 antibodies, there are 2 anti-AK2 rabbit monoclonal antibodies , 2 anti-AK2 rabbit polyclonal antibodies . All the AK2 anbodies are produced in house and all are in stock. AK2 antibody customerized service is available.

AK2 Gene

AK2 gene / cDNA is a protein-coding gene which located on 1p35.1. The AK2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.237 organisms have orthologs with human gene AK2.