May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
AKAP79/AKAP5 protein expression
Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
AKAP5 cDNA / gene is a gene with protein product which located on 14q23.3. The AKAP5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 188 organisms have orthologs with human gene AKAP5.