AKR1B1 Protein Overview: Sequence, Structure, Function and Protein Interaction

AKR1B1 Protein Overview

See aldehyde reductase (103830). Aldose reductase (EC 1.1.1.21) is a member of the monomeric, NADPH-dependent aldo-keto reductase family and participates in glucose metabolism and osmoregulation. It is believed to play a protective role against toxic aldehydes derived from lipid peroxidation and steroidogenesis that could affect cell growth/differentiation when accumulated (Lefrancois-Martinez et al., 2004). It is the first enzyme of the polyol pathway of sugar metabolism, is most abundantly expressed in adrenal gland, and has been implicated in diabetic complications (Shah et al., 1997).

AKR1B1 protein family

Belongs to the aldo/keto reductase family.

AKR1B1 protein name

Recommended name
Aldose reductase
Short name
AR
Aliases
aldose reductase, AR
Alternative name
Aldehyde reductase Aldo-keto reductase family 1 member B1

AKR1B1 Gene family protein

Aldo-keto reductases

AKR1B1 Protein Sequence

Species Human AKR1B1 protein
Length 316
Mass (Da) 35853
Sequence Human AKR1B1 protein sequence
Species Mouse AKR1B1 protein
Length 316
Mass (Da) 35732
Sequence Mouse AKR1B1 protein sequence
Species Rat AKR1B1 protein
Length 316
Mass (Da) 35797
Sequence Rat AKR1B1 protein sequence

AKR1B1 Protein Molecular Weight & PI

Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde reductase) (Aldo-keto reductase family 1 member B1)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 2-316 Aldose reductase.

Molecular weight (Da)

35722.21

Theoretical pI

6.55

AKR1B1 Protein Structure

FIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE
Deposited
2000-02-06   Released:  2001-02-07
Deposition Author(s)
Oka, M., Matsumoto, Y., Sugiyama, S., Tsuruta, N., Matsushima, M.
Organism(s)
Homo sapiens
Expression System
unidentified baculovirus
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.8000 Å
R-Value Free
0.278
R-Value Work
0.186
1EF3 From PDB

Human AKR1B1 protein Secondary structure

AKR1B1 Protein Interaction

Recombinant AKR1B1 Protein Feature

AKR1B1 Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
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