Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
AKR1C1 protein expression
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
AKR1C1 cDNA / gene is a gene with protein product which located on 10p15.1. The AKR1C1 gene is conserved in chimpanzee, Rhesus monkey, mouse, rat, and A.thaliana. 2 organisms have orthologs with human gene AKR1C1.