AKR1C3 Information: AKR1C3 Protein, AKR1C3 Antibody and AKR1C3 Gene

AKR1C3 Gene family

AKR1C3 Protein

AKR1C3 protein function

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

AKR1C3 protein expression

Tissue specificity

Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.

AKR1C3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

AKR1C3 Gene

AKR1C3 cDNA / gene is a gene with protein product which located on 10p15.1. The AKR1C3 gene is conserved in chimpanzee, dog, cow, mouse, and rat. 2 organisms have orthologs with human gene AKR1C3.