Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078).
AKR1E2/AKR1CL2 protein expression
Specifically expressed in testis (PubMed:12604216, PubMed:15118078). Expressed in testicular germ cells and testis interstitial cells (PubMed:15118078).
AKR1E2 cDNA / gene is a gene with protein product which located on 10p15.1. The AKR1E2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, A.thaliana, and rice. 91 organisms have orthologs with human gene AKR1E2.