Akr7a2 Information: Akr7a2 Protein, Akr7a2 Antibody and Akr7a2 Gene

Akr7a2 Gene family

Akr7a2 Protein

Akr7a2 protein function

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Akr7a2 protein expression

Tissue specificity

Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.

Akr7a2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

Akr7a2 Gene

AKR7A2 cDNA / gene is a gene with protein product which located on 1p36.13. The AKR7A2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, M.oryzae, and frog. 93 organisms have orthologs with human gene AKR7A2.