AKT3 Information: AKT3 Protein, AKT3 Antibody and AKT3 Gene

AKT3 Gene family

AKT3 Protein

AKT3 protein function

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.

AKT3 protein expression

Tissue specificity

In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.

AKT3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    479.00
  • Mass (KDa)
    55.00

AKT3 Antibody

There are 1 AKT3 antibodies which are validated in multiple tissues with various applications, including ELISA. There are 1 AKT3 antibody for ELISA. Among all these AKT3 antibodies, there are 1 anti-AKT3 rabbit polyclonal antibodies . All the AKT3 anbodies are produced in house and all are in stock. AKT3 antibody customerized service is available.

AKT3 Gene

AKT3 gene / cDNA is a protein-coding gene which located on 1q43-q44. The AKT3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.188 organisms have orthologs with human gene AKT3.