ALK-7 Information: ALK-7 Protein, ALK-7 Antibody and ALK-7 Gene

ALK-7 Gene family

ALK-7 Protein

ALK-7 protein function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}.

ALK-7 protein expression

Tissue specificity

Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.

ALK-7 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

ALK-7 Gene

ACVR1C gene / cDNA is a protein-coding gene which located on 2q24.1. The ACVR1C gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.229 organisms have orthologs with human gene ACVR1C.