ALK4/ACVR1B Information: ALK4/ACVR1B Protein, ALK4/ACVR1B Antibody and ALK4/ACVR1B Gene

ALK4/ACVR1B Gene family

ALK4/ACVR1B Protein

ALK4/ACVR1B protein function

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. {ECO:0000269|PubMed:12364468, ECO:0000269|PubMed:12639945, ECO:0000269|PubMed:18039968, ECO:0000269|PubMed:20226172, ECO:0000269|PubMed:8196624, ECO:0000269|PubMed:9032295, ECO:0000269|PubMed:9892009}.

ALK4/ACVR1B protein expression

Tissue specificity

Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.

ALK4/ACVR1B protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    505.00
  • Mass (KDa)
    56.00

ALK4/ACVR1B Antibody

There are 2 ALK4/ACVR1B antibodies which are validated in multiple tissues with various applications, including ELISA, WB. There are 2 ALK4/ACVR1B antibody for ELISA, 1 ALK4/ACVR1B antibody for WB. Among all these ALK4/ACVR1B antibodies, there are 1 anti-ALK4/ACVR1B mouse monoclonal antibodies , 1 anti-ALK4/ACVR1B rabbit polyclonal antibodies . All the ALK4/ACVR1B anbodies are produced in house and all are in stock. ALK4/ACVR1B antibody customerized service is available.

ALK4/ACVR1B Gene

ACVR1B gene / cDNA is a protein-coding gene which located on 12q13.13. The ACVR1B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.203 organisms have orthologs with human gene ACVR1B.