ALKBH1 Information: ALKBH1 Protein, ALKBH1 Antibody and ALKBH1 Gene

ALKBH1 Gene family

ALKBH1 Protein

ALKBH1 protein function

Dioxygenase that acts as on nucleic acids, such as DNA and tRNA (PubMed:18603530, PubMed:27745969, PubMed:27497299). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:18603530, PubMed:27497299). A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (PubMed:27745969, PubMed:27497299). Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (PubMed:27745969). In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (PubMed:27497299). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation, but with low activity (PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (PubMed:19959401). DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity).

ALKBH1 protein expression

Tissue specificity

Ubiquitous.

ALKBH1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    389.00
  • Mass (KDa)
    43.00

ALKBH1 Antibody

There are 1 ALKBH1 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, IP. There are 1 ALKBH1 antibody for WB, 1 ALKBH1 antibody for IHC-P, 1 ALKBH1 antibody for IP. Among all these ALKBH1 antibodies, there are 1 anti-ALKBH1 rabbit polyclonal antibodies . All the ALKBH1 anbodies are produced in house and all are in stock. ALKBH1 antibody customerized service is available.

ALKBH1 Gene

ALKBH1 cDNA / gene is a gene with protein product which located on 14q24.3. The ALKBH1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. 242 organisms have orthologs with human gene ALKBH1.