ALKBH3/ABH3 Information: ALKBH3/ABH3 Protein, ALKBH3/ABH3 Antibody and ALKBH3/ABH3 Gene

ALKBH3/ABH3 Gene family

ALKBH3/ABH3 Protein

ALKBH3/ABH3 protein function

Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:22055184, PubMed:16858410).

ALKBH3/ABH3 protein expression

Tissue specificity

Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon.

ALKBH3/ABH3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    286.00
  • Mass (KDa)
    33.00

ALKBH3/ABH3 Gene

ALKBH3 cDNA / gene is a gene with protein product which located on 11p11.2. The ALKBH3 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. 242 organisms have orthologs with human gene ALKBH3.