ALKBH5 Information: ALKBH5 Protein, ALKBH5 Antibody and ALKBH5 Gene

ALKBH5 Gene family

ALKBH5 Protein

ALKBH5 protein function

Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).

ALKBH5 protein expression

Tissue specificity

Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.

Induction

By hypoxia, directly activated by HIF1A. Expression is regulated by PRMT7.

ALKBH5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    394.00
  • Mass (KDa)
    44.00

ALKBH5 Antibody

There are 1 ALKBH5 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ICC/IF, IP. There are 1 ALKBH5 antibody for WB, 1 ALKBH5 antibody for IHC-P, 1 ALKBH5 antibody for ICC/IF, 1 ALKBH5 antibody for IP. Among all these ALKBH5 antibodies, there are 1 anti-ALKBH5 rabbit polyclonal antibodies . All the ALKBH5 anbodies are produced in house and all are in stock. ALKBH5 antibody customerized service is available.

ALKBH5 Gene

ALKBH5 cDNA / gene is a gene with protein product which located on 17p11.2. The ALKBH5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 233 organisms have orthologs with human gene ALKBH5.