ALKBH7 Information: ALKBH7 Protein, ALKBH7 Antibody and ALKBH7 Gene

ALKBH7 Gene family

ALKBH7 Protein

ALKBH7 protein function

May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).

ALKBH7 protein expression

Tissue specificity

Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.

ALKBH7 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    221.00
  • Mass (KDa)
    24.00

ALKBH7 Gene

ALKBH7 cDNA / gene is a gene with protein product which located on 19p13.3. The ALKBH7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, and frog. 168 organisms have orthologs with human gene ALKBH7.