ALKBH8/ABH8 Information: ALKBH8/ABH8 Protein, ALKBH8/ABH8 Antibody and ALKBH8/ABH8 Gene

ALKBH8/ABH8 Gene family

ALKBH8/ABH8 Protein

ALKBH8/ABH8 protein function

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).

ALKBH8/ABH8 protein expression

Tissue specificity

Widely expressed, with highest expression in spleen, followed by pancreas and lung.

Induction

Up-regulated after DNA damage. Induction is mediated via ATM.

ALKBH8/ABH8 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    664.00
  • Mass (KDa)
    75.00

ALKBH8/ABH8 Gene

ALKBH8 cDNA / gene is a gene with protein product which located on 11q22.3. The ALKBH8 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog. 240 organisms have orthologs with human gene ALKBH8.