ALOX12 Information: ALOX12 Protein, ALOX12 Antibody and ALOX12 Gene

ALOX12 Gene family

ALOX12 Protein

ALOX12 protein function

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.

ALOX12 protein expression

Tissue specificity

Expressed in vascular smooth muscle cells.

Induction

Down-regulated upon starvation, by UV-irradiation and 15-lipoxygenase metabolites.

ALOX12 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    663.00
  • Mass (KDa)
    75.00

ALOX12 Antibody

There are 1 ALOX12 antibodies which are validated in multiple tissues with various applications, including WB. There are 1 ALOX12 antibody for WB. Among all these ALOX12 antibodies, there are 1 anti-ALOX12 rabbit polyclonal antibodies . All the ALOX12 anbodies are produced in house and all are in stock. ALOX12 antibody customerized service is available.

ALOX12 Gene

ALOX12 cDNA / gene is a gene with protein product which located on 17p13.1. The ALOX12 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and M.oryzae. 87 organisms have orthologs with human gene ALOX12.