ALOX15 Information: ALOX15 Protein, ALOX15 Antibody and ALOX15 Gene

ALOX15 Gene family

ALOX15 Protein

ALOX15 protein function

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

ALOX15 protein expression

Tissue specificity

Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.

Induction

Up-regulated by UV-irradiation.

ALOX15 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    662.00
  • Mass (KDa)
    74.00

ALOX15 Gene

ALOX15 cDNA / gene is a gene with protein product which located on 17p13.2. The ALOX15 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 74 organisms have orthologs with human gene ALOX15.