ALOXE3 Information: ALOXE3 Protein, ALOXE3 Antibody and ALOXE3 Gene

ALOXE3 Gene family

ALOXE3 Protein

ALOXE3 protein function

Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

ALOXE3 protein expression

Tissue specificity

Predominantly expressed in skin.

ALOXE3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    711.00
  • Mass (KDa)
    80.00

ALOXE3 Gene

ALOXE3 cDNA / gene is a gene with protein product which located on 17p13.1. The ALOXE3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. 107 organisms have orthologs with human gene ALOXE3.