alpha-2-macroglobulin Information: alpha-2-macroglobulin Protein, alpha-2-macroglobulin Antibody and alpha-2-macroglobulin Gene

alpha-2-macroglobulin Gene family

alpha-2-macroglobulin Protein

alpha-2-macroglobulin protein function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

alpha-2-macroglobulin protein expression

Tissue specificity

Secreted in plasma.

Induction

Unlike the rat protein, which is an acute phase protein, this protein is always in circulation at high levels.

alpha-2-macroglobulin protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,474.00
  • Mass (KDa)
    163.00

alpha-2-macroglobulin Antibody

There are 2 alpha-2-macroglobulin antibodies which are validated in multiple tissues with various applications, including ELISA. There are 2 alpha-2-macroglobulin antibody for ELISA. Among all these alpha-2-macroglobulin antibodies, there are 1 anti-alpha-2-macroglobulin rabbit monoclonal antibodies , 1 anti-alpha-2-macroglobulin rabbit polyclonal antibodies . All the alpha-2-macroglobulin anbodies are produced in house and all are in stock. alpha-2-macroglobulin antibody customerized service is available.

alpha-2-macroglobulin Gene

A2M cDNA / gene is a protein coding gene. The A2M gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 65 organisms have orthologs with human gene A2M.