Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509).
ALX1 cDNA / gene is a gene with protein product which located on 12q21.31. The ALX1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. 233 organisms have orthologs with human gene ALX1.