ALYREF Information: ALYREF Protein, ALYREF Antibody and ALYREF Gene

ALYREF Gene family

ALYREF Protein

ALYREF protein function

Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability.

ALYREF protein expression

Tissue specificity

Expressed in a wide variety of cancer types.

ALYREF protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    257.00
  • Mass (KDa)
    26.00

ALYREF Gene

ALYREF cDNA / gene is a gene with protein product which located on 17q25.3. The ALYREF gene is conserved in Rhesus monkey, dog, cow, and rat. 213 organisms have orthologs with human gene ALYREF.