AMFR Information: AMFR Protein, AMFR Antibody and AMFR Gene

AMFR Gene family

AMFR Protein

AMFR protein function

E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

AMFR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    643.00
  • Mass (KDa)
    72.00

AMFR Antibody

There are 1 AMFR antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 AMFR antibody for IHC-P. Among all these AMFR antibodies, there are 1 anti-AMFR rabbit polyclonal antibodies . All the AMFR anbodies are produced in house and all are in stock. AMFR antibody customerized service is available.

AMFR Gene

AMFR cDNA / gene is a gene with protein product which located on 16q13. The AMFR gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and frog. 230 organisms have orthologs with human gene AMFR.