AMPK alpha 1/PRKAA1 Gene Sequence, Family, Fuction and Expression Information
AMPK alpha 1/PRKAA1 cDNA / Gene Overview
PRKAA1 gene / cDNA is a protein-coding gene which located on 5p13.1. The PRKAA1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, rice, and frog.233 organisms have orthologs with human gene PRKAA1.
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
AMPK alpha 1/PRKAA1 cDNA / Gene Sequence
LOCUS NM_006251 5085 bp mRNA linear PRI 15-JUL-2018
Homo sapiens protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), transcript variant 1, mRNA.
This sequence information is just for reference only.
AMPK alpha 1/PRKAA1 cDNA / Gene Alias
AMPK alpha 1/PRKAA1 cDNA / Gene Expression
Ubiquitous expression in gall bladder (RPKM 18.4), thyroid (RPKM 16.3) and 25 other tissues