Angiopoietin-4 Protein Overview: Sequence, Structure, Function and Protein Interaction

Angiopoietin-4 Protein Overview

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1 (ANGPT1; 601667), as well as a naturally occurring antagonist, angiopoietin-2 (ANGPT2; 601922), both of which act by means of the TIE2 receptor (600221). Using homology-based cloning approaches, Valenzuela et al. (1999) identified 2 novel angiopoietins: angiopoietin-3 (Angpt3) in mouse, and angiopoietin-4 (ANGPT4) in human. They also identified several more distantly related sequences that did not seem to be true angiopoietins in that they did not bind to TIE receptors. Although angiopoietin-3 and angiopoietin-4 are more structurally diverged from each other than are the mouse and human versions of angiopoietin-1 and angiopoietin-2, they appear to represent the mouse and human counterparts of the same gene locus, as revealed in chromosomal localization studies of all the angiopoietins in mouse and human. The structural divergence of angiopoietin-3 and angiopoietin-4 appeared to underlie the diverging functions of these counterparts. Northern blot analysis showed that angiopoietin-3 was expressed as a major 2.5- and a minor 1.1-kb transcript in multiple mouse tissues, whereas angiopoietin-4 was expressed as a major 5- and a minor 4-kb transcript primarily in human lung.

Angiopoietin-4 protein name

Recommended name
Short name
Alternative name
Angiopoietin-3 ANG-3

Angiopoietin-4 Protein Sequence

Species Human Angiopoietin-4 protein
Length 503
Mass (Da) 56849
Sequence Human Angiopoietin-4 protein sequence
Species Mouse Angiopoietin-4 protein
Length 509
Mass (Da) 57805
Sequence Mouse Angiopoietin-4 protein sequence
Mass (Da)

Angiopoietin-4 Protein Molecular Weight & PI

Angiopoietin-4 precursor (ANG-4) (Angiopoietin-3) (ANG-3)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 25-503 Angiopoietin-4.

Molecular weight (Da)


Theoretical pI


Angiopoietin-4 Protein Interaction

Recombinant Angiopoietin-4 Protein Feature

Angiopoietin-4 Protein, Human, Recombinant (hFc Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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