ATF1 Gene Sequence, Family, Fuction and Expression Information
ATF1 cDNA / Gene Overview
ATF1 gene / cDNA is a protein-coding gene which located on 12q13.12. The ATF1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.203 organisms have orthologs with human gene ATF1.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
ATF1 cDNA / Gene Sequence
LOCUS NM_005171 2505 bp mRNA linear PRI 24-JUN-2018
Homo sapiens activating transcription factor 1 (ATF1), mRNA.
This sequence information is just for reference only.