B7-H4 Gene Sequence, Family, Fuction and Expression Information

B7-H4 cDNA / Gene Overview

VTCN1 gene / cDNA is a protein-coding gene which located on 1p13.1-p12. The VTCN1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.209 organisms have orthologs with human gene VTCN1.

B7-H4 cDNA / Gene Function

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

B7-H4 cDNA / Gene Sequence

LOCUS
LOCUS NM_024626 2652 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens V-set domain containing T cell activation inhibitor 1 (VTCN1), transcript variant 1, mRNA.
ACCESSION
NM_024626
VERSION
NM_024626.3

This sequence information is just for reference only.

B7-H4 Family & Reagents

B7-H4 Gene family reagents (V-set domain containing)

Approved Symbol Reagent list
MCAM
NCR2
CD28
BTN3A1
Vsir
AXL
NCR3
CD33
IGSF8
NECTIN2
Approved Symbol Reagent list
SLAMF6
JAML
CD7
PSG6
CD79A
PIGR
NECTIN1
TREM2
FCAMR
HAVCR1

B7-H4 Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
ICAM5
IL12B
CD200
TEK
ALCAM
NTRK1
AGER
IL18BP
CDON
HepaCAM2
Approved Symbol Reagent list
LY9
ICAM3
VCAM1
CEACAM6
IL6R
CEACAM8
IL1RAPL1
IL18R1
MUSK
FCGR3A

B7-H4 cDNA / Gene Alias

  • B7 family member
  • H4
  • B7 superfamily member 1
  • B7H4
  • B7-H4
  • B7S1
  • B7X
  • FLJ22418

B7-H4 cDNA / Gene Expression

Biased expression in kidney (RPKM 5.0), pancreas (RPKM 2.8) and 9 other tissues