BACE1 Gene Sequence, Family, Fuction and Expression Information

BACE1 cDNA / Gene Overview

BACE1 gene / cDNA is a protein-coding gene which located on 11q23.3. The BACE1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.225 organisms have orthologs with human gene BACE1.

BACE1 cDNA / Gene Function

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]

BACE1 cDNA / Gene Sequence

LOCUS NM_001207048 5226 bp mRNA linear PRI 11-AUG-2018
Homo sapiens beta-secretase 1 (BACE1), transcript variant e, mRNA.

This sequence information is just for reference only.

BACE1 cDNA / Gene Expression

Ubiquitous expression in pancreas (RPKM 33.5), brain (RPKM 30.2) and 24 other tissues