BAF53b/ACTL6B Information: BAF53b/ACTL6B Protein, BAF53b/ACTL6B Antibody and BAF53b/ACTL6B Gene

BAF53b/ACTL6B Gene family

BAF53b/ACTL6B Protein

BAF53b/ACTL6B protein function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).

BAF53b/ACTL6B protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    426.00
  • Mass (KDa)
    46.00

BAF53b/ACTL6B Gene

ACTL6B cDNA / gene is a gene with protein product which located on 7q22.1. The ACTL6B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa. 128 organisms have orthologs with human gene ACTL6B.