BCRP/ABCG2 Information: BCRP/ABCG2 Protein, BCRP/ABCG2 Antibody and BCRP/ABCG2 Gene

BCRP/ABCG2 Gene family

BCRP/ABCG2 Protein

BCRP/ABCG2 protein function

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. {ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181}.

BCRP/ABCG2 protein expression

Tissue specificity

Highly expressed in placenta. Low expression in small intestine, liver and colon.

Induction

Up-regulated in brain tumors.

BCRP/ABCG2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    655.00
  • Mass (KDa)
    72.00

BCRP/ABCG2 Antibody

There are 4 BCRP/ABCG2 antibodies which are validated in multiple tissues with various applications, including WB, IP, IHC-P. There are 3 BCRP/ABCG2 antibody for WB, 1 BCRP/ABCG2 antibody for IP, 1 BCRP/ABCG2 antibody for IHC-P. Among all these BCRP/ABCG2 antibodies, there are 4 anti-BCRP/ABCG2 rabbit polyclonal antibodies . All the BCRP/ABCG2 anbodies are produced in house and all are in stock. BCRP/ABCG2 antibody customerized service is available.

BCRP/ABCG2 Gene

ABCG2 gene / cDNA is a protein-coding gene which located on 4q22.1. The ABCG2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.172 organisms have orthologs with human gene ABCG2.