Bim Information: Bim Protein, Bim Antibody and Bim Gene

Bim Gene family

Bim Protein

Bim protein function

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:9430630}.

Bim protein expression

Tissue specificity

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.

Induction

By ER stress in a DDIT3/CHOP-dependent manner.

Bim protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    198.00
  • Mass (KDa)
    22.00

Bim Antibody

There are 4 Bim antibodies which are validated in multiple tissues with various applications, including ELISA, WB, IHC-P. There are 3 Bim antibody for ELISA, 1 Bim antibody for WB, 1 Bim antibody for IHC-P. Among all these Bim antibodies, there are 4 anti-Bim rabbit polyclonal antibodies . All the Bim anbodies are produced in house and all are in stock. Bim antibody customerized service is available.

Bim Gene

BCL2L11 gene / cDNA is a protein-coding gene which located on 2q13. The BCL2L11 gene is conserved in Rhesus monkey, dog, mouse, rat, and frog.198 organisms have orthologs with human gene BCL2L11.