BMP10 Information: BMP10 Protein, BMP10 Antibody and BMP10 Gene

BMP10 Gene family

BMP10 Protein

BMP10 protein function

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. {ECO:0000269|PubMed:16049014, ECO:0000269|PubMed:17068149, ECO:0000269|PubMed:20608934}.

BMP10 protein expression

Tissue specificity

Detected in mammary epithelia (at protein level).

Induction

Down-regulated in some breast cancer subtypes and breast cancer cell lines.

BMP10 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    424.00
  • Mass (KDa)
    48.00

BMP10 Antibody

There are 1 BMP10 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 BMP10 antibody for IHC-P. Among all these BMP10 antibodies, there are 1 anti-BMP10 rabbit polyclonal antibodies . All the BMP10 anbodies are produced in house and all are in stock. BMP10 antibody customerized service is available.

BMP10 Gene

BMP10 gene / cDNA is a protein-coding gene which located on 2p13.3. The BMP10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.224 organisms have orthologs with human gene BMP10.