BTN3A1 Protein Overview: Sequence, Structure, Function and Protein Interaction

BTN3A1 Protein Overview

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (601610) and the BTN2 (e.g., BTN2A1; 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010).

BTN3A1 protein family

Belongs to the immunoglobulin superfamily. BTN/MOG family.

BTN3A1 protein name

Recommended name
Butyrophilin subfamily 3 member A1
BT3.1, BTF5, BTN3.1, CD277
Alternative name
CD antigen CD277

BTN3A1 Gene family protein

BTN3A1 Protein Sequence

Species Human BTN3A1 protein
Length 513
Mass (Da) 57677
Sequence Human BTN3A1 protein sequence
Mass (Da)
Mass (Da)

BTN3A1 Protein Molecular Weight & PI

Butyrophilin subfamily 3 member A1 precursor (CD277 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 30-513 Butyrophilin subfamily 3 member A1.

Molecular weight (Da)


Theoretical pI


BTN3A1 Protein Structure

Crystal Structure of the Human BTN3A1 Ectodomain in Complex with the 20.1 Single Chain Antibody
2012-05-18   Released:  2012-08-08
Deposition Author(s)
Palakodeti, A., Sandstrom, A., Sundaresan, L., Harly, C., Nedellec, S., Olive, D., Scotet, E., Bonneville, M., Adams, E.J.
Homo sapiens
Expression System
Trichoplusia ni, Escherichia coli
Experimental Data Snapshot
3.1400 Å
R-Value Free
R-Value Work
4F9L From PDB

Human BTN3A1 protein Secondary structure

BTN3A1 Protein Interaction

Recombinant BTN3A1 Protein Feature

BTN3A1 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE.
Low Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.

Recombinant BTN3A1 protein citations

BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells
Payne, KK;Mine, JA;Biswas, S;Chaurio, RA;Perales-Puchalt, A;Anadon, CM;Costich, TL;Harro, CM;Walrath, J;Ming, Q;Tcyganov, E;Buras, AL;Rigolizzo, KE;Mandal, G;Lajoie, J;Ophir, M;Tchou, J;Marchion, D;Luca, VC;Bobrowicz, P;McLaughlin, B;Eskiocak, U;Schmidt, M;Cubillos-Ruiz, JR;Rodriguez, PC;Gabrilovich, DI;Conejo-Garcia, JR;
Science (New York, N.Y.)

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