Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
C11orf17/AKIP1 protein expression
Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.
AKIP1 cDNA / gene is a gene with protein product which located on 11p15.4. The AKIP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 198 organisms have orthologs with human gene AKIP1.