C5 Information: C5 Protein, C5 Antibody and C5 Gene

C5 Gene family

C5 Protein

C5 protein function

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. {ECO:0000269|PubMed:8182049}.

C5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,676.00
  • Mass (KDa)
    188.00

C5 Antibody

There are 9 C5 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), ELISA(Det), IHC-P. There are 5 C5 antibody for ELISA, 2 C5 antibody for ELISA(Cap), 1 C5 antibody for ELISA(Det), 1 C5 antibody for IHC-P. Among all these C5 antibodies, there are 5 anti-C5 mouse monoclonal antibodies , 3 anti-C5 rabbit monoclonal antibodies , 1 anti-C5 rabbit polyclonal antibodies . All the C5 anbodies are produced in house and all are in stock. C5 antibody customerized service is available.

C5 Gene

C5 gene / cDNA is a protein-coding gene which located on 9q33.2. The C5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, and frog.219 organisms have orthologs with human gene C5.