C8A Gene Sequence, Family, Fuction and Expression Information

C8A cDNA / Gene Overview

C8A cDNA / gene is a gene with protein product which located on 1p32.2. The C8A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 242 organisms have orthologs with human gene C8A.

C8A cDNA / Gene Function

C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]

C8A cDNA / Gene Sequence

LOCUS
HUMC8AS 2397 bp mRNA linear PRI 07-NOV-1994
DEFINITION
Human complement protein C8 alpha subunit mRNA, complete cds.
ACCESSION
M16974
VERSION
M16974.1

This sequence information is just for reference only.

C8A Family & Reagents

Gene family

C8A Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C3
C6
CD46
CFB
CFH
CFHR2
Approved Symbol Reagent list
C2
C5
C7
CD59
CFD
CFHR1
CR2

C8A cDNA / Gene Expression

Restricted expression toward liver (RPKM 74.5)