CCRK Protein Overview: Sequence, Structure, Function and Protein Interaction

CCRK Protein Overview

The cyclin-dependent protein kinases (CDKs) that regulate cell cycle transitions are themselves regulated by inhibitory and activating phosphorylation. CDK-activating kinases (CAKs) phosphorylate conserved threonine residues such as thr161 in CDC2 (116940) and thr160 in CDK2 (116953). CCRK/p42 is a monomeric CAK that specifically phosphorylates CDK2 thr160 and functions as a CDK2-activating kinase (Liu et al., 2004).

CCRK protein family

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

CCRK protein name

Recommended name
Cyclin-dependent kinase 20
Aliases
p42

CCRK Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-346 Cyclin-dependent kinase 20.

Molecular weight (Da)

38694.81

Theoretical pI

6.27

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