CD13 Information: CD13 Protein, CD13 Antibody and CD13 Gene

CD13 Gene family

CD13 Protein

CD13 protein function

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. {ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}.; (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. {ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485, ECO:0000269|PubMed:9367365}.; (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}.

CD13 protein expression

Tissue specificity

Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.

Induction

Estradiol and IL8/interleukin-8 decrease enzymatic activity in vitro in endometrial stromal cells by 40% and 30%, respectively.

CD13 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    967.00
  • Mass (KDa)
    109.00

CD13 Antibody

There are 14 CD13 antibodies which are validated in multiple tissues with various applications, including ELISA, WB, IHC-P, IP, ICC/IF. There are 8 CD13 antibody for ELISA, 6 CD13 antibody for WB, 9 CD13 antibody for IHC-P, 3 CD13 antibody for IP, 1 CD13 antibody for ICC/IF. Among all these CD13 antibodies, there are 3 anti-CD13 mouse monoclonal antibodies , 5 anti-CD13 rabbit monoclonal antibodies , 6 anti-CD13 rabbit polyclonal antibodies . All the CD13 anbodies are produced in house and all are in stock. CD13 antibody customerized service is available.

CD13 Gene

ANPEP gene / cDNA is a protein-coding gene which located on 15q26.1. The ANPEP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.187 organisms have orthologs with human gene ANPEP.