CD166/ALCAM Information: CD166/ALCAM Protein, CD166/ALCAM Antibody and CD166/ALCAM Gene

CD166/ALCAM Gene family

CD166/ALCAM Protein

CD166/ALCAM protein function

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). {ECO:0000250|UniProtKB:P42292, ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}.; Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. {ECO:0000269|PubMed:15496415}.

CD166/ALCAM protein expression

Tissue specificity

Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).

Induction

Up-regulated by TNF and IFNG (at protein level).

CD166/ALCAM protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    583.00
  • Mass (KDa)
    65.00

CD166/ALCAM Antibody

There are 24 CD166/ALCAM antibodies which are validated in multiple tissues with various applications, including FCM, ICC/IF, ELISA, WB, IHC-P, IP. There are 11 CD166/ALCAM antibody for FCM, 1 CD166/ALCAM antibody for ICC/IF, 13 CD166/ALCAM antibody for ELISA, 5 CD166/ALCAM antibody for WB, 3 CD166/ALCAM antibody for IHC-P, 2 CD166/ALCAM antibody for IP. Among all these CD166/ALCAM antibodies, there are 5 anti-CD166/ALCAM mouse monoclonal antibodies , 10 anti-CD166/ALCAM rabbit polyclonal antibodies , 9 anti-CD166/ALCAM rabbit monoclonal antibodies . All the CD166/ALCAM anbodies are produced in house and all are in stock. CD166/ALCAM antibody customerized service is available.

CD166/ALCAM Gene

ALCAM gene / cDNA is a protein-coding gene which located on 3q13.11. The ALCAM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.214 organisms have orthologs with human gene ALCAM.