CD2 Protein Overview: Sequence, Structure, Function and Protein Interaction

CD2 Protein Overview

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it (summary by Sewell et al., 1986).

CD2 protein name

Recommended name
T-cell surface antigen CD2
Alternative name
Erythrocyte receptor LFA-2 LFA-3 receptor Rosette receptor T-cell surface antigen T11/Leu-5 CD antigen CD2

CD2 Gene family protein

CD2 Protein Sequence

Species Human CD2 protein
Length 351
Mass (Da) 39448
Sequence Human CD2 protein sequence
Species Mouse CD2 protein
Length 344
Mass (Da) 38415
Sequence Mouse CD2 protein sequence
Species Rat CD2 protein
Length 344
Mass (Da) 38413
Sequence Rat CD2 protein sequence

CD2 Protein Molecular Weight & PI

T-cell surface antigen CD2 precursor (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD2 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 25-351 T-cell surface antigen CD2.

Molecular weight (Da)


Theoretical pI


CD2 Protein Structure

2006-10-09   Released:  2006-11-06
Deposition Author(s)
Moncalian, G., Cardenes, N., Deribe, Y.L., Spinola-Amilibia, M., Dikic, I., Bravo, J.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
2.9000 Å
R-Value Free
R-Value Work
2J7I From PDB

Human CD2 protein Secondary structure

CD2 Protein Interaction

Recombinant CD2 Protein Feature

CD2 Protein, Human, Recombinant (ECD, His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD2 His (Cat:10982-H08H) at 2 μg/ml (100 μl/well) can bind Human CD58 hFc(Cat:12409-H02H), the EC50 of Human CD58 hFc is 7.0-28.0 ng/mL.

Recombinant CD2 protein citations

CD2-mediated regulation of peripheral CD4(+)  CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim
Kashiwakura, Y;Sakurai, D;Kanno, Y;Hashiguchi, M;Kobayashi, A;Kurosu, A;Tokudome, S;Kobata, T;Kojima, H;

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