CD226 Gene Sequence, Family, Fuction and Expression Information

CD226 cDNA / Gene Overview

CD226 gene / cDNA is a protein-coding gene which located on 18q22.2. The CD226 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.213 organisms have orthologs with human gene CD226.

CD226 cDNA / Gene Function

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

CD226 cDNA / Gene Sequence

LOCUS
LOCUS NM_006566 2844 bp mRNA linear PRI 03-JUN-2018
DEFINITION
Homo sapiens CD226 molecule (CD226), transcript variant 1, mRNA.
ACCESSION
NM_006566
VERSION
NM_006566.3

This sequence information is just for reference only.

CD226 Family & Reagents

CD226 Gene family reagents (CD molecules)

Approved Symbol Reagent list
CEACAM5
ICOS
ENG
IL18RAP
CD82
FCGR2A
LAG3
CDCP1
INSR
CD69
Approved Symbol Reagent list
TLR4
TNFRSF1B
CSF1R
SLAMF7
GYPC
CLEC10A
ICAM3
LAMP2
ART1
GP1BB

CD226 Gene family reagents (V-set domain containing)

Approved Symbol Reagent list
TREML2
VSIG8
CADM1
CD28
KDR
AXL
JAM3
CD79A
CD86
CD8B
Approved Symbol Reagent list
PVR
SLAMF7
NECTIN4
NCR2
PSG6
HEPACAM
CD7
HHLA2
MPZL3
SIGLEC15

CD226 cDNA / Gene Alias

  • DNAM1
  • DNAM-1
  • PTA1
  • TLiSA1

CD226 cDNA / Gene Expression

Broad expression in spleen (RPKM 2.4), lymph node (RPKM 1.3) and 15 other tissues

Recombinant CD226 protein citations

Title
CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells
Year
2020
Author
Braun, M;Aguilera, A;Sundarrajan, A;Corvino, D;Stannard, K;Krumeich, S;Das, I;Lima, L;Meza Guzman, L;Li, K;Li, R;Salim, N;Jorge, M;Ham, S;Kelly, G;Vari, F;Lepletier, A;Raghavendra, A;Pearson, S;Madore, J;Jacquelin, S;Effern, M;Quine, B;Koufariotis, L;Casey, M;Nakamura, K;Seo, E;Hölzel, M;Geyer, M;Kristiansen, G;Taheri, T;Ahern, E;Hughes, B;Wilmott, J;Long, G;Scolyer, R;Batstone, M;Landsberg, J;Dietrich, D;Pop, O;Flatz, L;Dougall, W;Veillette, A;Nicholson, S;Möller, A;Johnston, R;Martinet, L;Smyth, M;Bald, T;
Journal
Immunity