CDK9/CDC2L4 Gene Sequence, Family, Fuction and Expression Information
CDK9/CDC2L4 cDNA / Gene Overview
CDK9 cDNA / gene is a gene with protein product which located on 9q34.11. The CDK9 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, and frog. 241 organisms have orthologs with human gene CDK9.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
CDK9/CDC2L4 cDNA / Gene Sequence
HUMCDCTRK 1461 bp mRNA linear PRI 01-JUN-1994
Homo sapiens CDC2-related kinase (PITALRE) mRNA, complete cds.
This sequence information is just for reference only.