CPN1 Gene Sequence, Family, Fuction and Expression Information
CPN1 cDNA / Gene Overview
CPN1 cDNA / gene is a gene with protein product which located on 10q24.2. The CPN1 gene is conserved in dog, cow, mouse, rat, chicken, zebrafish, and frog. 238 organisms have orthologs with human gene CPN1.
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
CPN1 cDNA / Gene Sequence
X14329 1702 bp mRNA linear PRI 07-OCT-2008
Human mRNA for carboxypeptidase N small subunit (EC 184.108.40.206).
This sequence information is just for reference only.