CPN1 Gene Sequence, Family, Fuction and Expression Information

CPN1 cDNA / Gene Overview

CPN1 cDNA / gene is a gene with protein product which located on 10q24.2. The CPN1 gene is conserved in dog, cow, mouse, rat, chicken, zebrafish, and frog. 238 organisms have orthologs with human gene CPN1.

CPN1 cDNA / Gene Function

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

CPN1 cDNA / Gene Sequence

LOCUS
X14329 1702 bp mRNA linear PRI 07-OCT-2008
DEFINITION
Human mRNA for carboxypeptidase N small subunit (EC 3.4.17.3).
ACCESSION
X14329
VERSION
X14329.1

This sequence information is just for reference only.

CPN1 Family & Reagents

Gene family

CPN1 Gene family reagents (M14 carboxypeptidases)

Approved Symbol Reagent list
CPA1
CPB1
CPE
CPVL
Approved Symbol Reagent list
CPA2
CPB2
CPM
SCPEP1

CPN1 cDNA / Gene Alias

  • anaphylatoxin inactivator
  • arginine carboxypeptidase
  • carboxypeptidase K
  • kininase I
  • lysine carboxypeptidase

CPN1 cDNA / Gene Expression

Restricted expression toward liver (RPKM 18.6)